The Taylor Lab studies genetic and epigenetic mechanisms of blood cancer pathogenesis. We have several translational projects investigating targeted cancer therapies, single-cell sequencing studies, and CRISPR screening projects. We use molecular biology, genomics, proteomics, and mouse modeling to determine the mechanisms and potential targetable weaknesses of blood cancers. The current efforts in the lab include studying alterations in nuclear export function due to mutations or overexpression of the nuclear exporter XPO1 and investigating resistance mechanisms to noncovalent BTK inhibitors as well as means to overcome these resistance mechanisms.

Check out our projects below!